반응형 Project118 8. Reference[Characteristics study of TATA box through comparison of elastic modulus according to DNA sequence] Reference [1] NAMD User's Guide Version CVS-2016-09-08, M.Bhandarkar외 공저 [2] Seungho Choe and Sean X.Sun, “The elasticity of alpha-helices”, The Journal of Chemical Physics(2005)7 [3] VMD User’s Guide, NIH Biomedical Research Center for Macromolecular Modeling and Bioinformatics, December 23, 2014 [4] 여영구, “쉽게배우는 MATLAB 입문과 활용 3판”, 아진, 2014 [5] 국가나노기술정책센터(나노물질 시뮬레이션기술) [6] 구조 생물 정보학 연구 협동 조합(RCS.. 2021. 11. 12. 7. Conclusion[Characteristics study of TATA box through comparison of elastic modulus according to DNA sequence] 7.1. Conclusion 물리학과 생물학이 융합된 생물물리학이라는 학문으로 DNA의 중요한 물리적 특성인 탄성에 대해 연구하였다. 본 연구에서는 다른 선행 연구와는 달리 염기조성에 따른 DNA의 탄성을 연구하였다. 또한 음파를 이용하는 간접적이거나 광집게를 이용하는 고가의 장비가 필요한 실험 설계를 필요로 하지 않는 분자동력학 시뮬레이션과 MATLAB을 이용하였다. 또한 기존연구들과는 달리 염기비율에 따른 탄성을 비교할 수 있었다. 정량적으로 분석하는 방법으로 Helix의 탄성계수에 관한 선행연구, 많은 논문에서 인용하는 Kratky-porod model(worm like chain model)를 참고하였으며 2중 나선구조인 DNA의 탄성계수를 구하기 위해 실험을 설계하였다. 염기조성에 따른 연구결과.. 2021. 11. 12. 6. Result[Characteristics study of TATA box through comparison of elastic modulus according to DNA sequence] 6.1. Graph(MATLAB) The horizontal axis of the log omega graph means the torsion angle w_i, and the vertical axis means -ln(P(w_i)). The graph should appear in the form of a parabola, but the bending modulus, twisting modulus, and intrinsic torsional values could not be derived because fitting was not performed well with the parabola. Instead, it was analyzed through graph reformation, using tha.. 2021. 11. 12. 5. Research[Characteristics study of TATA box through comparison of elastic modulus according to DNA sequence] 5.1. Modeling A previous study, 'Helix's Elasticity Study', shows that in order to form a coordinate system necessary for the calculation process, a two-dimensional figure must be created using atoms. The methods attempted in this study include a method to obtain elasticity by thinking of the template and auxiliary strands of DNA as individual helices, a method to create a two-dimensional figure.. 2021. 11. 11. 4. Theoretical background[Characteristics study of TATA box through comparison of elastic modulus according to DNA sequence] 4.1. Deoxyribonucleic acid (DNA) and deoxyribose DNA is a type of nucleic acid and is a substance that mainly stores genetic information of living things in the nucleus of a cell. The main function of DNA is to store information over a long period of time. The structure of DNA appears to be a helical structure as a whole, which corresponds to a skeleton and consists of nucleobases between the sk.. 2021. 11. 11. 3. Introduction[Characteristics study of TATA box through comparison of elastic modulus according to DNA sequence] 3.1. Motivation In the life science class, I learned the DNA sequence called TATA box. Specifically, the TATA box binds to the TATA junction protein and acts as a common promoter of genes. However, other promoter sequences are recognized only by specific transcription factors, which play an important role in cell differentiation during development. This TATA box was named because of the high rat.. 2021. 11. 11. 이전 1 2 3 4 5 6 7 ··· 20 다음 반응형
